ARTICLE Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents Jidong Zhang, Christine Lair, Christine Roubert, Anna Upton, James C. Sacchettini, Sophie Lagrange, Open AccessPublished:February 23, 2023DOI:https://doi.org/10.1016/j.cell.2023.01.043 https://www.cell.com/cell/fulltext/S0092-8674(23)00102-2 Highlights Structure-based medicinal chemistry leads to an optimized sequanamycin-derived lead molecule, SEQ-9 Sequanamycins are macrolide antibiotics able to overcome inherent Mtb macrolide resistance SEQ-9 is able to adjust its binding mode to […]